Agonist-specific voltage-dependent gating of lysosomal two-pore Na(+) channels

Mammalian two-pore-channels (TPC1, 2; TPCN1, TPCN2) are ubiquitously- expressed, PI(3,5)P(2)-activated, Na(+)-selective channels in the endosomes and lysosomes that regulate luminal pH homeostasis, membrane trafficking, and Ebola viral infection. Whereas the channel activity of TPC1 is strongly depe...

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Bibliographic Details
Published in:eLife
Main Authors: Zhang, Xiaoli, Chen, Wei, Li, Ping, Calvo, Raul, Southall, Noel, Hu, Xin, Bryant-Genevier, Melanie, Feng, Xinghua, Geng, Qi, Gao, Chenlang, Yang, Meimei, Tang, Kaiyuan, Ferrer, Marc, Marugan, Juan Jose, Xu, Haoxing
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2019
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6905855/
https://ncbi.nlm.nih.gov/pubmed/31825310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51423
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