Agonist-specific voltage-dependent gating of lysosomal two-pore Na(+) channels

Mammalian two-pore-channels (TPC1, 2; TPCN1, TPCN2) are ubiquitously- expressed, PI(3,5)P(2)-activated, Na(+)-selective channels in the endosomes and lysosomes that regulate luminal pH homeostasis, membrane trafficking, and Ebola viral infection. Whereas the channel activity of TPC1 is strongly depe...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Zhang, Xiaoli, Chen, Wei, Li, Ping, Calvo, Raul, Southall, Noel, Hu, Xin, Bryant-Genevier, Melanie, Feng, Xinghua, Geng, Qi, Gao, Chenlang, Yang, Meimei, Tang, Kaiyuan, Ferrer, Marc, Marugan, Juan Jose, Xu, Haoxing
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2019
Pynciau:
Neuroscience
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6905855/
https://ncbi.nlm.nih.gov/pubmed/31825310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51423
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg