Mechanisms of hyperexcitability in Alzheimer’s disease hiPSC-derived neurons and cerebral organoids vs isogenic controls

Human Alzheimer’s disease (AD) brains and transgenic AD mouse models manifest hyperexcitability. This aberrant electrical activity is caused by synaptic dysfunction that represents the major pathophysiological correlate of cognitive decline. However, the underlying mechanism for this excessive excit...

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Dettagli Bibliografici
Pubblicato in:eLife
Autori principali: Ghatak, Swagata, Dolatabadi, Nima, Trudler, Dorit, Zhang, XiaoTong, Wu, Yin, Mohata, Madhav, Ambasudhan, Rajesh, Talantova, Maria, Lipton, Stuart A
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2019
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6905854/
https://ncbi.nlm.nih.gov/pubmed/31782729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50333
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