Islet-Derived eATP Fuels Autoreactive CD8(+) T Cells and Facilitates the Onset of Type 1 Diabetes

Extracellular ATP (eATP) activates T cells by engaging the P2X7R receptor. We identified two loss-of-function P2X7R mutations that are protective against type 1 diabetes (T1D) and thus hypothesized that eATP/P2X7R signaling may represent an early step in T1D onset. Specifically, we observed that in...

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Veröffentlicht in:Diabetes
Hauptverfasser: Tezza, Sara, Ben Nasr, Moufida, D’Addio, Francesca, Vergani, Andrea, Usuelli, Vera, Falzoni, Simonetta, Bassi, Roberto, Dellepiane, Sergio, Fotino, Carmen, Rossi, Chiara, Maestroni, Anna, Solini, Anna, Corradi, Domenico, Giani, Elisa, Mameli, Chiara, Bertuzzi, Federico, Pezzolesi, Marcus G., Wasserfall, Clive H., Atkinson, Mark A., Füchtbauer, Ernst-Martin, Ricordi, Camillo, Folli, Franco, Di Virgilio, Francesco, Pileggi, Antonello, Dhe-Paganon, Sirano, Zuccotti, Gian Vincenzo, Fiorina, Paolo
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2018
Schlagworte:
Immunology and Transplantation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6905486/
https://ncbi.nlm.nih.gov/pubmed/30065030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-1227
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