PD-L1 genetic overexpression or pharmacological restoration in hematopoietic stem and progenitor cells reverses autoimmune diabetes

Immunologically based clinical trials performed thus far have failed to cure type 1 diabetes (T1D), in part because these approaches were nonspecific. Because the disease is driven by autoreactive CD4 T cells, which destroy β cells, transplantation of hematopoietic stem and progenitor cells (HSPCs)...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Transl Med
Prif Awduron: Nasr, Moufida Ben, Tezza, Sara, D’Addio, Francesca, Mameli, Chiara, Usuelli, Vera, Maestroni, Anna, Corradi, Domenico, Belletti, Silvana, Albarello, Luca, Becchi, Gabriella, Fadini, Gian Paolo, Schuetz, Christian, Markmann, James, Wasserfall, Clive, Zon, Leonard, Zuccotti, Gian Vincenzo, Fiorina, Paolo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6171337/
https://ncbi.nlm.nih.gov/pubmed/29141886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aam7543
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