PD-L1 genetic overexpression or pharmacological restoration in hematopoietic stem and progenitor cells reverses autoimmune diabetes

Immunologically based clinical trials performed thus far have failed to cure type 1 diabetes (T1D), in part because these approaches were nonspecific. Because the disease is driven by autoreactive CD4 T cells, which destroy β cells, transplantation of hematopoietic stem and progenitor cells (HSPCs)...

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Vydáno v:Sci Transl Med
Hlavní autoři: Nasr, Moufida Ben, Tezza, Sara, D’Addio, Francesca, Mameli, Chiara, Usuelli, Vera, Maestroni, Anna, Corradi, Domenico, Belletti, Silvana, Albarello, Luca, Becchi, Gabriella, Fadini, Gian Paolo, Schuetz, Christian, Markmann, James, Wasserfall, Clive, Zon, Leonard, Zuccotti, Gian Vincenzo, Fiorina, Paolo
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6171337/
https://ncbi.nlm.nih.gov/pubmed/29141886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aam7543
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