Islet-Derived eATP Fuels Autoreactive CD8(+) T Cells and Facilitates the Onset of Type 1 Diabetes

Extracellular ATP (eATP) activates T cells by engaging the P2X7R receptor. We identified two loss-of-function P2X7R mutations that are protective against type 1 diabetes (T1D) and thus hypothesized that eATP/P2X7R signaling may represent an early step in T1D onset. Specifically, we observed that in...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Tezza, Sara, Ben Nasr, Moufida, D’Addio, Francesca, Vergani, Andrea, Usuelli, Vera, Falzoni, Simonetta, Bassi, Roberto, Dellepiane, Sergio, Fotino, Carmen, Rossi, Chiara, Maestroni, Anna, Solini, Anna, Corradi, Domenico, Giani, Elisa, Mameli, Chiara, Bertuzzi, Federico, Pezzolesi, Marcus G., Wasserfall, Clive H., Atkinson, Mark A., Füchtbauer, Ernst-Martin, Ricordi, Camillo, Folli, Franco, Di Virgilio, Francesco, Pileggi, Antonello, Dhe-Paganon, Sirano, Zuccotti, Gian Vincenzo, Fiorina, Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2018
Assuntos:
Immunology and Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6905486/
https://ncbi.nlm.nih.gov/pubmed/30065030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-1227
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