Selective Inhibition of Nuclear Export With Oral Selinexor for Treatment of Relapsed or Refractory Multiple Myeloma

PURPOSE: Selinexor, a first-in-class, oral, selective exportin 1 (XPO1) inhibitor, induces apoptosis in cancer cells through nuclear retention of tumor suppressor proteins and the glucocorticoid receptor, along with inhibition of translation of oncoprotein mRNAs. We studied selinexor in combination...

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Publicado en:J Clin Oncol
Main Authors: Vogl, Dan T., Dingli, David, Cornell, Robert Frank, Huff, Carol Ann, Jagannath, Sundar, Bhutani, Divaya, Zonder, Jeffrey, Baz, Rachid, Nooka, Ajay, Richter, Joshua, Cole, Craig, Vij, Ravi, Jakubowiak, Andrzej, Abonour, Rafat, Schiller, Gary, Parker, Terri L., Costa, Luciano J., Kaminetzky, David, Hoffman, James E., Yee, Andrew J., Chari, Ajai, Siegel, David, Fonseca, Rafael, Van Wier, Scott, Ahmann, Gregory, Lopez, Ilsel, Kauffman, Michael, Shacham, Sharon, Saint-Martin, Jean-Richard, Picklesimer, Carla D., Choe-Juliak, Cassandra, Stewart, A. Keith
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Clinical Oncology 2018
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ORIGINAL REPORTS
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6905485/
https://ncbi.nlm.nih.gov/pubmed/29381435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2017.75.5207
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