Selective Inhibition of Nuclear Export With Oral Selinexor for Treatment of Relapsed or Refractory Multiple Myeloma

PURPOSE: Selinexor, a first-in-class, oral, selective exportin 1 (XPO1) inhibitor, induces apoptosis in cancer cells through nuclear retention of tumor suppressor proteins and the glucocorticoid receptor, along with inhibition of translation of oncoprotein mRNAs. We studied selinexor in combination...

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Bibliografiske detaljer
Udgivet i:J Clin Oncol
Main Authors: Vogl, Dan T., Dingli, David, Cornell, Robert Frank, Huff, Carol Ann, Jagannath, Sundar, Bhutani, Divaya, Zonder, Jeffrey, Baz, Rachid, Nooka, Ajay, Richter, Joshua, Cole, Craig, Vij, Ravi, Jakubowiak, Andrzej, Abonour, Rafat, Schiller, Gary, Parker, Terri L., Costa, Luciano J., Kaminetzky, David, Hoffman, James E., Yee, Andrew J., Chari, Ajai, Siegel, David, Fonseca, Rafael, Van Wier, Scott, Ahmann, Gregory, Lopez, Ilsel, Kauffman, Michael, Shacham, Sharon, Saint-Martin, Jean-Richard, Picklesimer, Carla D., Choe-Juliak, Cassandra, Stewart, A. Keith
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Clinical Oncology 2018
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ORIGINAL REPORTS
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6905485/
https://ncbi.nlm.nih.gov/pubmed/29381435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2017.75.5207
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