TGFβRI antagonist inhibits HIV-1 Nef-induced CC chemokine family ligand 2 (CCL2) in the brain and prevents spatial learning impairment

BACKGROUND: HIV-1–associated neurocognitive disorders (HAND) progression is related to continued inflammation despite undetectable viral loads and may be caused by early viral proteins expressed by latently infected cells. Astrocytes represent an HIV reservoir in the brain where the early viral neur...

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Bibliografiske detaljer
Udgivet i:J Neuroinflammation
Main Authors: Chompre, Gladys, Martinez-Orengo, Neysha, Cruz, Myrella, Porter, James T., Noel, Richard J.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6905066/
https://ncbi.nlm.nih.gov/pubmed/31829243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-019-1664-4
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