TGFβRI antagonist inhibits HIV-1 Nef-induced CC chemokine family ligand 2 (CCL2) in the brain and prevents spatial learning impairment

BACKGROUND: HIV-1–associated neurocognitive disorders (HAND) progression is related to continued inflammation despite undetectable viral loads and may be caused by early viral proteins expressed by latently infected cells. Astrocytes represent an HIV reservoir in the brain where the early viral neur...

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Veröffentlicht in:J Neuroinflammation
Hauptverfasser: Chompre, Gladys, Martinez-Orengo, Neysha, Cruz, Myrella, Porter, James T., Noel, Richard J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6905066/
https://ncbi.nlm.nih.gov/pubmed/31829243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-019-1664-4
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