TGFβRI antagonist inhibits HIV-1 Nef-induced CC chemokine family ligand 2 (CCL2) in the brain and prevents spatial learning impairment

BACKGROUND: HIV-1–associated neurocognitive disorders (HAND) progression is related to continued inflammation despite undetectable viral loads and may be caused by early viral proteins expressed by latently infected cells. Astrocytes represent an HIV reservoir in the brain where the early viral neur...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Neuroinflammation
Auteurs principaux: Chompre, Gladys, Martinez-Orengo, Neysha, Cruz, Myrella, Porter, James T., Noel, Richard J.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2019
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6905066/
https://ncbi.nlm.nih.gov/pubmed/31829243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-019-1664-4
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