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Evaluation of irrational dose assignment definitions using the continual reassessment method
BACKGROUND: This paper studies the notion of irrational dose assignment in phase I clinical trials. This property was recently defined by Zhou and colleagues as a dose assignment that fails to de-escalate the dose when 2 of 3, 3 of 6, or 4 of 6 patients have experienced a dose-limiting toxicity even...
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| Gepubliceerd in: | Clin Trials |
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| Hoofdauteurs: | , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2019
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6904537/ https://ncbi.nlm.nih.gov/pubmed/31547691 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774519873316 |
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