All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia

Ecotropic virus integration site 1 (EVI1), whose overexpression characterizes a particularly aggressive subtype of acute myeloid leukemia (AML), enhanced anti-leukemic activities of all-trans retinoic acid (atRA) in cell lines and patient samples. However, the drivers of leukemia formation, therapy...

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Pubblicato in:Cell Death Dis
Autori principali: Nguyen, Chi Huu, Bauer, Katharina, Hackl, Hubert, Schlerka, Angela, Koller, Elisabeth, Hladik, Anastasiya, Stoiber, Dagmar, Zuber, Johannes, Staber, Philipp B., Hoelbl-Kovacic, Andrea, Purton, Louise E., Grebien, Florian, Wieser, Rotraud
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6904467/
https://ncbi.nlm.nih.gov/pubmed/31822659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-2172-2
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