Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination

The NLRP3 inflammasome is a multiprotein oligomer responsible for activation of the inflammatory response by promoting the maturation and secretion of the pro-inflammatory cytokines IL-1β and IL-18. Dysregulation of this inflammasome has been linked to several autoimmune diseases, indicating that NL...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Rao, Zebing, Chen, Xin, Wu, Junxian, Xiao, Mengjun, Zhang, Jing, Wang, Binghao, Fang, Lei, Zhang, Hongjie, Wang, Xiaoming, Yang, Shuo, Chen, Yunzi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6904361/
https://ncbi.nlm.nih.gov/pubmed/31866999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02783
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