Helix breaking transition in the S4 of HCN channel is critical for hyperpolarization-dependent gating

In contrast to most voltage-gated ion channels, hyperpolarization- and cAMP gated (HCN) ion channels open on hyperpolarization. Structure-function studies show that the voltage-sensor of HCN channels are unique but the mechanisms that determine gating polarity remain poorly understood. All-atom mole...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Kasimova, Marina A, Tewari, Debanjan, Cowgill, John B, Ursuleaz, Willy Carrasquel, Lin, Jenna L, Delemotte, Lucie, Chanda, Baron
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2019
Assuntos:
Structural Biology and Molecular Biophysics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6904216/
https://ncbi.nlm.nih.gov/pubmed/31774399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.53400
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