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Developmental SMAD6 Loss Leads to Blood Vessel Hemorrhage and Disrupted Endothelial Cell Junctions

The BMP pathway regulates developmental processes including angiogenesis, yet its signaling outputs are complex and context-dependent. Recently, we showed that SMAD6, an intracellular BMP inhibitor expressed in endothelial cells, decreases vessel sprouting and branching both in vitro and in zebrafis...

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Bibliographic Details
Published in:Dev Biol
Main Authors: Wylie, Lyndsay A, Mouillesseaux, Kevin P, Chong, Diana C, Bautch, Victoria L
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6903908/
https://ncbi.nlm.nih.gov/pubmed/30098998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2018.07.027
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