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Human telomerase reverse transcriptase regulation by DNA methylation, transcription factor binding and alternative splicing (Review)

The catalytic subunit of telomerase, human telomerase reverse transcriptase (hTERT), plays an essential role in telomere maintenance to oppose cellular senescence and, is highly regulated in normal and cancerous cells. Regulation of hTERT occurs through multiple avenues, including a unique pattern o...

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Bibliografske podrobnosti
izdano v:Int J Oncol
Main Authors: Avin, Brittany A., Umbricht, Christopher B., Zeiger, Martha A.
Format: Artigo
Jezik:Inglês
Izdano: D.A. Spandidos 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6903903/
https://ncbi.nlm.nih.gov/pubmed/27779655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2016.3743
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