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TLR9 signaling mediates adaptive immunity following systemic AAV gene therapy
An ongoing concern of in vivo gene therapy is adaptive immune responses against the protein product of a transgene, particularly for recessive diseases in which antigens are not presented to lymphocytes during central tolerance induction. Here we show that Toll-like receptor 9 (TLR9) signaling activ...
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| Publicado no: | Cell Immunol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6903695/ https://ncbi.nlm.nih.gov/pubmed/31703913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2019.103997 |
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