HIV-1 Vif Triggers Cell Cycle Arrest by Degrading Cellular PPP2R5 Phospho-regulators

HIV-1 Vif hijacks a cellular ubiquitin ligase complex to degrade antiviral APOBEC3 enzymes and PP2A phosphatase regulators (PPP2R5A–E). APOBEC3 counteraction is essential for viral pathogenesis. However, Vif also functions through an unknown mechanism to induce G2 cell cycle arrest. Here, deep mutag...

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Publicat a:Cell Rep
Autors principals: Salamango, Daniel J., Ikeda, Terumasa, Moghadasi, Seyed Arad, Wang, Jiayi, McCann, Jennifer L., Serebrenik, Artur A., Ebrahimi, Diako, Jarvis, Matthew C., Brown, William L., Harris, Reuben S.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6903395/
https://ncbi.nlm.nih.gov/pubmed/31665623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.09.057
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