Coenzyme Q(10) alleviates tacrolimus-induced mitochondrial dysfunction in kidney

The major side effect of tacrolimus (Tac) is nephrotoxicity. We studied whether supplementation of coenzyme Q(10), (CoQ(10)) a potent antioxidant, can reduce Tac-induced nephrotoxicity via improving mitochondrial function. In an in vitro study, CoQ(10) reduced the production of Tac-induced mitochond...

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Veröffentlicht in:FASEB J
Hauptverfasser: Yu, Ji Hyun, Lim, Sun Woo, Luo, Kang, Cui, Sheng, Quan, Yi, Shin, Yoo Jin, Lee, Kyung Eun, Kim, Hong Lim, Ko, Eun Jeong, Chung, Byung Ha, Kim, Ju Hwan, Chung, Sang J., Yang, Chul Woo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2019
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6902707/
https://ncbi.nlm.nih.gov/pubmed/31431058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900386RR
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