Surfen-mediated blockade of extratumoral chondroitin sulfate glycosaminoglycans inhibits glioblastoma invasion

Invasive spread of glioblastoma (GBM) is linked to changes in chondroitin sulfate (CS) proteoglycan (CSPG)–associated sulfated glycosaminoglycans (GAGs) that are selectively up-regulated in the tumor microenvironment (TME). We hypothesized that inhibiting CS-GAG signaling in the TME would stem GBM i...

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Udgivet i:FASEB J
Main Authors: Logun, Meghan T., Wynens, Kallie E., Simchick, Gregory, Zhao, Wujun, Mao, Leidong, Zhao, Qun, Mukherjee, Subhas, Brat, Daniel J., Karumbaiah, Lohitash
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6902699/
https://ncbi.nlm.nih.gov/pubmed/31398290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201802610RR
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