Surfen-mediated blockade of extratumoral chondroitin sulfate glycosaminoglycans inhibits glioblastoma invasion

Invasive spread of glioblastoma (GBM) is linked to changes in chondroitin sulfate (CS) proteoglycan (CSPG)–associated sulfated glycosaminoglycans (GAGs) that are selectively up-regulated in the tumor microenvironment (TME). We hypothesized that inhibiting CS-GAG signaling in the TME would stem GBM i...

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Vydáno v:FASEB J
Hlavní autoři: Logun, Meghan T., Wynens, Kallie E., Simchick, Gregory, Zhao, Wujun, Mao, Leidong, Zhao, Qun, Mukherjee, Subhas, Brat, Daniel J., Karumbaiah, Lohitash
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2019
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6902699/
https://ncbi.nlm.nih.gov/pubmed/31398290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201802610RR
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