Surfen-mediated blockade of extratumoral chondroitin sulfate glycosaminoglycans inhibits glioblastoma invasion

Invasive spread of glioblastoma (GBM) is linked to changes in chondroitin sulfate (CS) proteoglycan (CSPG)–associated sulfated glycosaminoglycans (GAGs) that are selectively up-regulated in the tumor microenvironment (TME). We hypothesized that inhibiting CS-GAG signaling in the TME would stem GBM i...

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Detalles Bibliográficos
Publicado en:FASEB J
Main Authors: Logun, Meghan T., Wynens, Kallie E., Simchick, Gregory, Zhao, Wujun, Mao, Leidong, Zhao, Qun, Mukherjee, Subhas, Brat, Daniel J., Karumbaiah, Lohitash
Formato: Artigo
Idioma:Inglês
Publicado: Federation of American Societies for Experimental Biology 2019
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6902699/
https://ncbi.nlm.nih.gov/pubmed/31398290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201802610RR
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