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Defective neurogenesis and schizophrenia-like behavior in PARP-1-deficient mice
In the current study we present evidence suggesting that PARP-1 regulates neurogenesis and its deficiency may result in schizophrenia-like behavioral deficits in mice. PARP-1 knockout neural stem cells exhibited a marked upregulation of embryonic stem cell phosphatase that can suppress the prolifera...
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| Publié dans: | Cell Death Dis |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6901579/ https://ncbi.nlm.nih.gov/pubmed/31819047 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-2174-0 |
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