Structural and biophysical characterizations of HIV-1 matrix trimer binding to lipid nanodiscs shed light on virus assembly

During the late phase of the HIV-1 replication cycle, the viral Gag polyproteins are targeted to the plasma membrane for assembly. The Gag-membrane interaction is mediated by binding of Gag's N-terminal myristoylated matrix (MA) domain to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)). The...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Murphy, R. Elliot, Samal, Alexandra B., Vlach, Jiri, Mas, Vicente, Prevelige, Peter E., Saad, Jamil S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901326/
https://ncbi.nlm.nih.gov/pubmed/31640987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010997
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