The anthelmintic drug praziquantel activates a schistosome transient receptor potential channel

The anthelmintic drug praziquantel (PZQ) is used to treat schistosomiasis, a neglected tropical disease that affects over 200 million people worldwide. PZQ causes Ca(2+) influx and spastic paralysis of adult worms and rapid vacuolization of the worm surface. However, the mechanism of action of PZQ r...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Park, Sang-Kyu, Gunaratne, Gihan S., Chulkov, Evgeny G., Moehring, Francie, McCusker, Paul, Dosa, Peter I., Chan, John D., Stucky, Cheryl L., Marchant, Jonathan S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Accelerated Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901322/
https://ncbi.nlm.nih.gov/pubmed/31653697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.AC119.011093
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