Activation of host transient receptor potential (TRP) channels by praziquantel stereoisomers

The anthelmintic praziquantel (±PZQ) serves as a highly effective antischistosomal therapy. ±PZQ causes a rapid paralysis of adult schistosome worms and deleterious effects on the worm tegument. In addition to these activities against the parasite, ±PZQ also modulates host vascular tone in blood ves...

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Udgivet i:PLoS Negl Trop Dis
Main Authors: Gunaratne, Gihan S., Yahya, Nawal A., Dosa, Peter I., Marchant, Jonathan S.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927461/
https://ncbi.nlm.nih.gov/pubmed/29668703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0006420
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