An arginase-based system for selection of transfected CHO cells without the use of toxic chemicals

Polyamines have essential roles in cell proliferation, DNA replication, transcription, and translation processes, with intracellular depletion of putrescine, spermidine, and spermine resulting in cellular growth arrest and eventual death. Serum-free media for CHO-K1 cells require putrescine suppleme...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Capella Roca, Berta, Lao, Nga, Barron, Niall, Doolan, Padraig, Clynes, Martin
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2019
Subjects:
Methods and Resources
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901305/
https://ncbi.nlm.nih.gov/pubmed/31666335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011162
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