Intravitreal Therapy Against the Complement Factor C5 Prevents Retinal Degeneration in an Experimental Autoimmune Glaucoma Model

In glaucoma, studies revealed an involvement of the complement system. In an experimental autoimmune glaucoma model, immunization with an optic nerve homogenate antigen (ONA) led to retinal ganglion cell (RGC) loss, while intraocular pressure (IOP) remained unchanged. Here, we investigated the thera...

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Udgivet i:Front Pharmacol
Main Authors: Reinehr, Sabrina, Gomes, Sara C., Gassel, Caroline J., Asaad, M. Ali, Stute, Gesa, Schargus, Marc, Dick, H. Burkhard, Joachim, Stephanie C.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901014/
https://ncbi.nlm.nih.gov/pubmed/31849650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01381
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