APOL1 Kidney Risk Variants Induce Cell Death via Mitochondrial Translocation and Opening of the Mitochondrial Permeability Transition Pore

BACKGROUND: Genetic Variants in Apolipoprotein L1 (APOL1) are associated with large increases in CKD rates among African Americans. Experiments in cell and mouse models suggest that these risk-related polymorphisms are toxic gain-of-function variants that cause kidney dysfunction, following a recess...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Shah, Shrijal S., Lannon, Herbert, Dias, Leny, Zhang, Jia-Yue, Alper, Seth L., Pollak, Martin R., Friedman, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2019
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6900802/
https://ncbi.nlm.nih.gov/pubmed/31558683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019020114
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