Apolipoprotein L1 (APOL1) risk variant toxicity depends on the haplotype background.

The apolipoprotein L1 (APOL1) risk variants G1 and G2 are associated with high rates of kidney disease in African Americans in genetic studies. However, our understanding of APOL1 biology has lagged far behind. Here we report that engineering G1 and G2 mutations on unnatural haplotype backgrounds in...

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Bibliographic Details
Published in:Kidney Int
Main Authors: Lannon, Herbert, Shah, Shrijal, Dias, Leny, Blackler, Daniel, Alper, Seth L., Pollak, Martin R., Friedman, David J.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6907738/
https://ncbi.nlm.nih.gov/pubmed/31611067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2019.07.010
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