Apolipoprotein L1 (APOL1) risk variant toxicity depends on the haplotype background.

The apolipoprotein L1 (APOL1) risk variants G1 and G2 are associated with high rates of kidney disease in African Americans in genetic studies. However, our understanding of APOL1 biology has lagged far behind. Here we report that engineering G1 and G2 mutations on unnatural haplotype backgrounds in...

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Dettagli Bibliografici
Pubblicato in:Kidney Int
Autori principali: Lannon, Herbert, Shah, Shrijal, Dias, Leny, Blackler, Daniel, Alper, Seth L., Pollak, Martin R., Friedman, David J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6907738/
https://ncbi.nlm.nih.gov/pubmed/31611067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2019.07.010
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