Distinct Roles for Condensin’s Two ATPase Sites in Chromosome Condensation

Condensin is a conserved SMC complex that uses its ATPase machinery to structure genomes, but how it does so is largely unknown. We show that condensin’s ATPase has a dual role in chromosome condensation. Mutation of one ATPase site impairs condensation, while mutating the second site results in hyp...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Elbatsh, Ahmed M.O., Kim, Eugene, Eeftens, Jorine M., Raaijmakers, Jonne A., van der Weide, Robin H., García-Nieto, Alberto, Bravo, Sol, Ganji, Mahipal, uit de Bos, Jelmi, Teunissen, Hans, Medema, René H., de Wit, Elzo, Haering, Christian H., Dekker, Cees, Rowland, Benjamin D.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6900782/
https://ncbi.nlm.nih.gov/pubmed/31629658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.09.020
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