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Real-time imaging of DNA loop extrusion by condensin

It has been hypothesized that Structural Maintenance of Chromosomes (SMC) protein complexes such as condensin and cohesin spatially organize chromosomes by extruding DNA into large loops. Here, we provide unambiguous evidence for loop extrusion by directly visualizing the formation and processive ex...

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發表在:Science
Main Authors: Ganji, Mahipal, Shaltiel, Indra A., Bisht, Shveta, Kim, Eugene, Kalichava, Ana, Haering, Christian H., Dekker, Cees
格式: Artigo
語言:Inglês
出版: 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329450/
https://ncbi.nlm.nih.gov/pubmed/29472443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aar7831
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