ROS-mediated PI3K activation drives mitochondrial transfer from stromal cells to hematopoietic stem cells in response to infection

Hematopoietic stem cells (HSCs) undergo rapid expansion in response to stress stimuli. Here we investigate the bioenergetic processes which facilitate the HSC expansion in response to infection. We find that infection by Gram-negative bacteria drives an increase in mitochondrial mass in mammalian HS...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Mistry, Jayna J., Marlein, Christopher R., Moore, Jamie A., Hellmich, Charlotte, Wojtowicz, Edyta E., Smith, James G. W., Macaulay, Iain, Sun, Yu, Morfakis, Adam, Patterson, Angela, Horton, Rebecca H., Divekar, Devina, Morris, Christopher J., Haestier, Anna, Di Palma, Federica, Beraza, Naiara, Bowles, Kristian M., Rushworth, Stuart A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6900710/
https://ncbi.nlm.nih.gov/pubmed/31727843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1913278116
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