Acute myeloid leukemia induces protumoral p16INK4a-driven senescence in the bone marrow microenvironment

Acute myeloid leukemia (AML) is an age-related disease that is highly dependent on the bone marrow (BM) microenvironment. With increasing age, tissues accumulate senescent cells, characterized by an irreversible arrest of cell proliferation and the secretion of a set of proinflammatory cytokines, ch...

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Udgivet i:Blood
Main Authors: Abdul-Aziz, Amina M., Sun, Yu, Hellmich, Charlotte, Marlein, Christopher R., Mistry, Jayna, Forde, Eoghan, Piddock, Rachel E., Shafat, Manar S., Morfakis, Adam, Mehta, Tarang, Di Palma, Federica, Macaulay, Iain, Ingham, Christopher J., Haestier, Anna, Collins, Angela, Campisi, Judith, Bowles, Kristian M., Rushworth, Stuart A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2019
Fag:
Myeloid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6356984/
https://ncbi.nlm.nih.gov/pubmed/30401703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-04-845420
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