Acute myeloid leukemia induces protumoral p16INK4a-driven senescence in the bone marrow microenvironment

Acute myeloid leukemia (AML) is an age-related disease that is highly dependent on the bone marrow (BM) microenvironment. With increasing age, tissues accumulate senescent cells, characterized by an irreversible arrest of cell proliferation and the secretion of a set of proinflammatory cytokines, ch...

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Dades bibliogràfiques
Publicat a:Blood
Autors principals: Abdul-Aziz, Amina M., Sun, Yu, Hellmich, Charlotte, Marlein, Christopher R., Mistry, Jayna, Forde, Eoghan, Piddock, Rachel E., Shafat, Manar S., Morfakis, Adam, Mehta, Tarang, Di Palma, Federica, Macaulay, Iain, Ingham, Christopher J., Haestier, Anna, Collins, Angela, Campisi, Judith, Bowles, Kristian M., Rushworth, Stuart A.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2019
Matèries:
Myeloid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6356984/
https://ncbi.nlm.nih.gov/pubmed/30401703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-04-845420
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