Acute myeloid leukemia induces protumoral p16INK4a-driven senescence in the bone marrow microenvironment

Acute myeloid leukemia (AML) is an age-related disease that is highly dependent on the bone marrow (BM) microenvironment. With increasing age, tissues accumulate senescent cells, characterized by an irreversible arrest of cell proliferation and the secretion of a set of proinflammatory cytokines, ch...

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Enregistré dans:
Détails bibliographiques
Publié dans:Blood
Auteurs principaux: Abdul-Aziz, Amina M., Sun, Yu, Hellmich, Charlotte, Marlein, Christopher R., Mistry, Jayna, Forde, Eoghan, Piddock, Rachel E., Shafat, Manar S., Morfakis, Adam, Mehta, Tarang, Di Palma, Federica, Macaulay, Iain, Ingham, Christopher J., Haestier, Anna, Collins, Angela, Campisi, Judith, Bowles, Kristian M., Rushworth, Stuart A.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2019
Sujets:
Myeloid Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6356984/
https://ncbi.nlm.nih.gov/pubmed/30401703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-04-845420
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