Differentiation of leukemic blasts is not completely blocked in acute myeloid leukemia

Hematopoiesis, the formation of blood cells, involves the hierarchical differentiation of immature blast cells into mature, functional cell types and lineages of the immune system. Hematopoietic stem cells precisely regulate self-renewal versus differentiation to balance the production of blood cell...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Agarwal, Anupriya, Bolosky, William J., Wilson, David B., Eide, Christopher A., Olson, Susan B., Fan, Guang, Druker, Brian J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6900505/
https://ncbi.nlm.nih.gov/pubmed/31754026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904091116
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