Contribution of Streptokinase-Domains from Groups G and A (SK2a) Streptococci in Amidolytic/Proteolytic Activities and Fibrin-Dependent Plasminogen Activation: A Domain-Exchange Study

BACKGROUND: SK, a heterogeneous PA protein from groups A, C, and G streptococci (GAS, GCS, GGS, respectively) contains three structural domains (SKα, SKβ, and SK). Based on the variable region of SKβ, GAS-SK (ska) are clustered as SK1 and SK2 (including SK2a/SK2b), which show low and high FG-depende...

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Published in:Iran Biomed J
Main Authors: Rafipour, Maryam, Keramati, Malihe, Aslani, Mohammad Mehdi, Arashkia, Arash, Roohvand, Farzin
Format: Artigo
Language:Inglês
Published: Pasteur Institute of Iran 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6900475/
https://ncbi.nlm.nih.gov/pubmed/31454859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.29252/ibj.24.1.15
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