Artemisinin–(Iso)quinoline Hybrids by C−H Activation and Click Chemistry: Combating Multidrug‐Resistant Malaria

A substantial challenge worldwide is emergent drug resistance in malaria parasites against approved drugs, such as chloroquine (CQ). To address these unsolved CQ resistance issues, only rare examples of artemisinin (ART)‐based hybrids have been reported. Moreover, protein targets of such hybrids hav...

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Vydáno v:Angew Chem Int Ed Engl
Hlavní autoři: Çapcı, Aysun, Lorion, Mélanie M., Wang, Hui, Simon, Nina, Leidenberger, Maria, Borges Silva, Mariana C., Moreira, Diogo R. M., Zhu, Yongping, Meng, Yuqing, Chen, Jia Yun, Lee, Yew Mun, Friedrich, Oliver, Kappes, Barbara, Wang, Jigang, Ackermann, Lutz, Tsogoeva, Svetlana B.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6899722/
https://ncbi.nlm.nih.gov/pubmed/31290221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201907224
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