Artemisinin–(Iso)quinoline Hybrids by C−H Activation and Click Chemistry: Combating Multidrug‐Resistant Malaria

A substantial challenge worldwide is emergent drug resistance in malaria parasites against approved drugs, such as chloroquine (CQ). To address these unsolved CQ resistance issues, only rare examples of artemisinin (ART)‐based hybrids have been reported. Moreover, protein targets of such hybrids hav...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Çapcı, Aysun, Lorion, Mélanie M., Wang, Hui, Simon, Nina, Leidenberger, Maria, Borges Silva, Mariana C., Moreira, Diogo R. M., Zhu, Yongping, Meng, Yuqing, Chen, Jia Yun, Lee, Yew Mun, Friedrich, Oliver, Kappes, Barbara, Wang, Jigang, Ackermann, Lutz, Tsogoeva, Svetlana B.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6899722/
https://ncbi.nlm.nih.gov/pubmed/31290221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201907224
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