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Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI
ESSENTIALS: Zymogen PK is activated to PKa and cleaves substrates kininogen and FXII contributing to bradykinin generation. Monomeric PKa and dimeric homologue FXI utilize the N‐terminal apple domains to recruit substrates. A high‐resolution 1.3 Å structure of full‐length PKa reveals an active confo...
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| Publicado no: | J Thromb Haemost |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6899681/ https://ncbi.nlm.nih.gov/pubmed/30801944 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.14418 |
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