Statins can suppress DC‐mediated Th2 responses through the repression of OX40‐ligand and CCL17 expression

DCs and epithelial cell‐derived thymic stromal lymphopoietin (TSLP) have pivotal roles in allergic inflammation. TSLP stimulates myeloid DCs to express OX40‐ligand (OX40L) and CCL17, which trigger and maintain Th2 cell responses. We have previously shown that statins, which are HMG‐CoA reductase inh...

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Dettagli Bibliografici
Pubblicato in:Eur J Immunol
Autori principali: Inagaki‐Katashiba, Noriko, Ito, Tomoki, Inaba, Muneo, Azuma, Yoshiko, Tanaka, Akihiro, Phan, Vien, Kibata, Kayoko, Satake, Atsushi, Nomura, Shosaku
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2019
Soggetti:
Allergy and inflammation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6899642/
https://ncbi.nlm.nih.gov/pubmed/31269241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201847992
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