hESC-Derived Dopaminergic Transplants Integrate into Basal Ganglia Circuitry in a Preclinical Model of Parkinson’s Disease

Cell replacement is currently being explored as a therapeutic approach for neurodegenerative disease. Using stem cells as a source, transplantable progenitors can now be generated under conditions compliant with clinical application in patients. In this study, we elucidate factors controlling target...

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Publicado en:Cell Rep
Autores principales: Adler, Andrew F., Cardoso, Tiago, Nolbrant, Sara, Mattsson, Bengt, Hoban, Deirdre B., Jarl, Ulla, Wahlestedt, Jenny Nelander, Grealish, Shane, Björklund, Anders, Parmar, Malin
Formato: Artigo
Lenguaje:Inglês
Publicado: Cell Press 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6899556/
https://ncbi.nlm.nih.gov/pubmed/31553914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.08.058
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