ETS Proteins Bind with Glucocorticoid Receptors: Relevance for Treatment of Ewing Sarcoma

The glucocorticoid receptor (GR) acts as a ubiquitous cortisol-dependent transcription factor (TF). To identify co-factors, we used protein-fragment complementation assays and found that GR recognizes FLI1 and additional ETS family proteins, TFs relaying proliferation and/or migration signals. Follo...

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Publicat a:Cell Rep
Autors principals: Srivastava, Swati, Nataraj, Nishanth Belugali, Sekar, Arunachalam, Ghosh, Soma, Bornstein, Chamutal, Drago-Garcia, Diana, Roth, Lee, Romaniello, Donatella, Marrocco, Ilaria, David, Eyal, Gilad, Yuval, Lauriola, Mattia, Rotkopf, Ron, Kimchi, Adi, Haga, Yuya, Tsutsumi, Yasuo, Mirabeau, Olivier, Surdez, Didier, Zinovyev, Andrei, Delattre, Olivier, Kovar, Heinrich, Amit, Ido, Yarden, Yosef
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6899513/
https://ncbi.nlm.nih.gov/pubmed/31577941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.08.088
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