Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4(+) T Cell Metabolic Rewiring

Accumulation of lactate in the tissue microenvironment is a feature of both inflammatory disease and cancer. Here, we assess the response of immune cells to lactate in the context of chronic inflammation. We report that lactate accumulation in the inflamed tissue contributes to the upregulation of t...

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Detaylı Bibliyografya
Yayımlandı:Cell Metab
Asıl Yazarlar: Pucino, Valentina, Certo, Michelangelo, Bulusu, Vinay, Cucchi, Danilo, Goldmann, Katriona, Pontarini, Elena, Haas, Robert, Smith, Joanne, Headland, Sarah E., Blighe, Kevin, Ruscica, Massimiliano, Humby, Frances, Lewis, Myles J., Kamphorst, Jurre J., Bombardieri, Michele, Pitzalis, Costantino, Mauro, Claudio
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cell Press 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6899510/
https://ncbi.nlm.nih.gov/pubmed/31708446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.10.004
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