Effects of targeting the transcription factors Ikaros and Aiolos on B cell activation and differentiation in systemic lupus erythematosus

OBJECTIVE: To evaluate the effects of targeting Ikaros and Aiolos by cereblon modulator iberdomide on the activation and differentiation of B-cells from patients with systemic lupus erythematosus (SLE). METHODS: CD19(+) B-cells isolated from the peripheral blood of patients with SLE (n=41) were cult...

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Detalhes bibliográficos
Publicado no:Lupus Sci Med
Main Authors: Rivellese, Felice, Manou-Stathopoulou, Sotiria, Mauro, Daniele, Goldmann, Katriona, Pyne, Debasish, Rajakariar, Ravindra, Gordon, Patrick, Schafer, Peter, Bombardieri, Michele, Pitzalis, Costantino, Lewis, Myles J
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2021
Assuntos:
Immunology and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7970264/
https://ncbi.nlm.nih.gov/pubmed/33727237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/lupus-2020-000445
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