Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4(+) T Cell Metabolic Rewiring

Accumulation of lactate in the tissue microenvironment is a feature of both inflammatory disease and cancer. Here, we assess the response of immune cells to lactate in the context of chronic inflammation. We report that lactate accumulation in the inflamed tissue contributes to the upregulation of t...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Pucino, Valentina, Certo, Michelangelo, Bulusu, Vinay, Cucchi, Danilo, Goldmann, Katriona, Pontarini, Elena, Haas, Robert, Smith, Joanne, Headland, Sarah E., Blighe, Kevin, Ruscica, Massimiliano, Humby, Frances, Lewis, Myles J., Kamphorst, Jurre J., Bombardieri, Michele, Pitzalis, Costantino, Mauro, Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6899510/
https://ncbi.nlm.nih.gov/pubmed/31708446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.10.004
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