Disruption of the Key Ca(2+) Binding Site in the Selectivity Filter of Neuronal Voltage-Gated Calcium Channels Inhibits Channel Trafficking

Voltage-gated calcium channels are exquisitely Ca(2+) selective, conferred primarily by four conserved pore-loop glutamate residues contributing to the selectivity filter. There has been little previous work directly measuring whether the trafficking of calcium channels requires their ability to bin...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Meyer, James O., Dahimene, Shehrazade, Page, Karen M., Ferron, Laurent, Kadurin, Ivan, Ellaway, Joseph I.J., Zhao, Pengxiang, Patel, Tarun, Rothwell, Simon W., Lin, Peipeng, Pratt, Wendy S., Dolphin, Annette C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6899504/
https://ncbi.nlm.nih.gov/pubmed/31577951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.08.079
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