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Side Chain Orientation of Tryptophan Analogues Determines Agonism and Inverse Agonism in Short Ghrelin Peptides

We describe two synthetic amino acids with inverted side chain stereochemistry, which induce opposite biological activity. Phe(4) is an important part of the activation motif of ghrelin, and in short peptide inverse agonists such as KwFwLL‐NH(2), the aromatic core is necessary for inactivation of th...

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Bibliografski detalji
Izdano u:ChemMedChem
Glavni autori: Nicke, Lennart, Müller, Ronny, Geyer, Armin, Els‐Heindl, Sylvia
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6899459/
https://ncbi.nlm.nih.gov/pubmed/31442005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201900409
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