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Side Chain Orientation of Tryptophan Analogues Determines Agonism and Inverse Agonism in Short Ghrelin Peptides
We describe two synthetic amino acids with inverted side chain stereochemistry, which induce opposite biological activity. Phe(4) is an important part of the activation motif of ghrelin, and in short peptide inverse agonists such as KwFwLL‐NH(2), the aromatic core is necessary for inactivation of th...
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| Udgivet i: | ChemMedChem |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6899459/ https://ncbi.nlm.nih.gov/pubmed/31442005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201900409 |
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