Prevalence and Impact of Treatment Crossover in Cardiac Surgery Randomized Trials: A Meta‐Epidemiologic Study

BACKGROUND: Crossover dilutes treatment effect and reduces statistical power of intention‐to‐treat analysis. We examined incidence and impact on cardiac surgery randomized controlled trial (RCT) outcomes of crossover from experimental to control interventions, or vice versa. METHODS AND RESULTS: MED...

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Veröffentlicht in:J Am Heart Assoc
Hauptverfasser: Gaudino, Mario, Fremes, Stephen E., Ruel, Marc, Di Franco, Antonino, Di Mauro, Michele, Chikwe, Joanna, Frati, Giacomo, Girardi, Leonard N., Taggart, David P., Biondi‐Zoccai, Giuseppe
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
Schlagworte:
Systematic Review and Meta‐analysis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6898839/
https://ncbi.nlm.nih.gov/pubmed/31663420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.119.013711
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