Prevalence and Impact of Treatment Crossover in Cardiac Surgery Randomized Trials: A Meta‐Epidemiologic Study

BACKGROUND: Crossover dilutes treatment effect and reduces statistical power of intention‐to‐treat analysis. We examined incidence and impact on cardiac surgery randomized controlled trial (RCT) outcomes of crossover from experimental to control interventions, or vice versa. METHODS AND RESULTS: MED...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Am Heart Assoc
Auteurs principaux: Gaudino, Mario, Fremes, Stephen E., Ruel, Marc, Di Franco, Antonino, Di Mauro, Michele, Chikwe, Joanna, Frati, Giacomo, Girardi, Leonard N., Taggart, David P., Biondi‐Zoccai, Giuseppe
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2019
Sujets:
Systematic Review and Meta‐analysis
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6898839/
https://ncbi.nlm.nih.gov/pubmed/31663420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.119.013711
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