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The transition model of RTK activation: a quantitative framework for understanding RTK signaling and RTK modulator activity
Here, we discuss the transition model of receptor tyrosine kinase (RTK) activation, which is derived from biophysical investigations of RTK interactions and signaling. The model postulates that (1) RTKs can interact laterally to form dimers even in the absence of ligand, (2) different unliganded RTK...
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| Publicado no: | Cytokine Growth Factor Rev |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6898792/ https://ncbi.nlm.nih.gov/pubmed/31711797 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cytogfr.2019.10.004 |
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