The most common RNF43 mutant G659Vfs*41 is fully functional in inhibiting Wnt signaling and unlikely to play a role in tumorigenesis

RNF43 is an E3 ligase that inhibits Wnt signaling by ubiquitinating Wnt receptors for degradation. It is mutated in various cancer types with the most recurrent mutation being the frameshift G659Vfs*41 with frequencies of ~5–8% in colon, stomach and endometrial cancers. This mutation, a deletion of...

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Vydáno v:Sci Rep
Hlavní autoři: Tu, Jianghua, Park, Soohyun, Yu, Wangsheng, Zhang, Sheng, Wu, Ling, Carmon, Kendra, Liu, Qingyun J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6898356/
https://ncbi.nlm.nih.gov/pubmed/31811196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-54931-3
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